Acid-Labile Histone Phosphorylations
نویسندگان
چکیده
منابع مشابه
Acid-Labile Histone Phosphorylations
Eukaryotic DNA is packaged into chromatin, folded and compacted. The building blocks of mammalian chromatin are nucleosomes, which consist of octomers of histone proteins that can be post-translationally modified (PTM). Protein phosphorylation is one of the most abundant PTMs. Histones are phosphorylated mainly on serine, threonine, tyrosine as well as other sites such as arginine, histidine an...
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The majority of insulin-like growth factor (IGF)-I and IGF-II circulate in the serum as a complex with the insulin-like growth factor binding protein (IGFBP)-3 or IGFBP-5, and an acid-labile subunit (ALS). The function of ALS is to prolong the half-life of the IGF-I-IGFBP-3/IGFBP-5 binary complexes. Fourteen different mutations of the human IGFALS gene have been identified in 17 patients, sugge...
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The effect of sustained endotoxemia on expression of the acid-labile subunit (ALS) in relation to hepatic markers of altered GH and insulin sensitivity was examined. Juvenile rats were injected with endotoxin twice daily for 48 h, causing reduced food intake and attenuated growth. In pair-fed controls, food restriction caused marked suppression of ALS gene expression and circulating levels with...
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Intracellular delivery of active proteins presents an interesting approach in research and therapy. We created a protein transduction shuttle based on a new traceless click linker that combines the advantages of click reactions with implementation of reversible pH-sensitive bonds. The azidomethyl-methylmaleic anhydride (AzMMMan) linker was found compatible with different click chemistries, dem...
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ژورنال
عنوان ژورنال: MOJ Cell Science & Report
سال: 2017
ISSN: 2374-6912
DOI: 10.15406/mojcsr.2017.04.00088